Asian Journal of Research in Chemistry

V. Prabhakar ¹, K. Sudhakar Babu ¹, L. K. Ravindranath ¹, P. V. Ramana Reddy ², J. Latha ³

Affiliations
1 Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu, (A P), IN
2 Department of Chemistry, Loyola Degree College, Sri Yogivemana University, Kadapa , (A P), IN
3 Department of Bio-Technology, Sri Krishnadevaraya University College of Engineering and Technology, Anantapuramu – 515003 (A.P), IN

Abstract

A Novel Series of Compounds were synthesized by Condensation reaction of Carbazole aldehyde with Substituted Acetophenone derivatives 4 (a-d) in presence of alcoholic Sodium hydroxide Solution to get Chalcone Intermediates 5 (a-d), which were further treated hydroxyl amine hydrochloride in presence of Pyridine to get Iso Oxazoline Derivatives 6 (a-d). The latter were refluxed with Substituted Primary amines and formaldehyde for 8-10 hrs to get Mannich bases. The Structures of new compounds were confirmed by IR and 1H NMR and 13C NMR Spectral Data. Anti-bacterial and Anti-fungal Activities were evaluated and compared with the standard drugs, some compounds of the series Exhibited Promising Anti-microbial and Anti-fungal Activity Compared to Standard Drugs.

Keywords

Chalcone, Isoxazoline, Carbazoles, Mannich Bases, Anti-Bacterial, Antifungal Activity.

Full Text